Individuals of all ages are at risk for infection and severe disease. However, the probability of serious COVID-19 disease is higher in people aged ≥60 years, those living in a nursing home or long-term care facility, and those with chronic medical conditions. The COVID-19 Treatment Guidelines have been developed to inform clinicians how to care for patients with COVID-19. Because clinical information about the optimal management of COVID-19 is evolving quickly, these Guidelines will be updated frequently as published data and other authoritative information become available.

This is followed by care of the critically ill patients and therapeutic management of patients with COVID-19. Next is antiviral drugs, immune-based therapies, adjunctive therapy, and considerations for certain concomitant medications in patients with COVID-19. The Guidelines conclude with a section on COVID-19 and special populations.

The COVID-19 pandemic has exploded since cases were first reported in China in December 2019. As of December 5, 2020, more than 66 million cases of COVID-19—caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—have been reported globally, including more than 1.5 million deaths.

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