ATrain Education


Continuing Education for Health Professionals

Course Modules

  • Course Introduction
  1. What Is Terrorism?
  2. WMD and Terrorism
  3. Chemical Weapons
  4. Biological Weapons
  5. Radiological and Nuclear Weapons
  6. Health Alert Network (HAN)
  7. Resources and References
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NV: Bioterrorism and Weapons of Mass Destruction

This course fulfills the bioterrorism continuing education requirement for all nurses licensed or seeking licensure in Nevada.

It is not approved and does not fulfill the bioterrorism CE requirement for physicians or physician assistants.

  • Author:
    • Susan Walters Schmid, PhD

      Susan Schmid earned BA degrees in History and European Studies from George Mason University, a Master's degree in Public History from Appalachian State University, and a PhD in History from Arizona State University.

      In addition to her PhD she earned a Certificate in Scholarly Publishing from ASU. Susan has served as an editor for several scholarly presses. She worked as a desktop publishing specialist for Arizona State University and taught several courses for the History Department as well as "Introduction to Scholarly Publishing" and "Scholarly Editing" for the Scholarly Publishing Program.


  • Contact hours: 4
  • Pharmacotherapy hours: 2
  • Expiration date: February 1, 2020
  • Course price: $39

Course Summary

Defines terrorism, bioterrorism, and weapons of mass destruction and summarizes the diseases and agents most commonly used as chemical, biological, radiologic, and nuclear weapons. Outlines CDC recommendations and best practices and discusses the components and use of the Nevada Health Alert Network (HAN).

The following information applies to occupational therapy professionals:

  • Target Audience: Occupational Therapists, OTAs

Criteria for Successful Completion

80% or higher on the post test, a completed evaluation form, and payment where required. No partial credit will be awarded.

Conflict of Interest/Commercial Support

Conflict of Interest/Commercial Support

Accredited status does not imply endorsement by ATrain Education Inc. or by the American Nurses Credentialing Center or any other accrediting agency of any products discussed or displayed in this course. The planners and authors of this course have declared no conflict of interest and all information is provided fairly and without bias. No commercial support was received for this activity.

Accreditation Information

Objectives: When you finish this course you will be able to:

  • Discuss the parameters of terrorism and terrorism-like events as a twenty-first-century political and social challenge, and identify shared elements not dependent on mechanism or definition.
  • Define bioterrorism, chemical terrorism, and weapons of mass destruction (WMD) and list four main types of WMD.
  • For a chemical weapons event, summarize the agents most commonly used, the epidemiologic clues to and symptoms of a chemical release, and the appropriate first-receiver actions.
  • For a bioterrorism event, outline the CDC's three categories of agents, the clinical features of high-priority agents, and the best practices and reporting procedures for first receivers.
  • Describe the clinical features and treatment of exposure or injury from radiation, including acute radiation syndrome (ARS), and outline ways to protect staff and patients during a radiation incident.
  • Discuss the components and use of the Nevada Health Alert Network (NVHAN).

What Is Terrorism?

What comes to mind when you hear the word terrorism? Bombings, mass casualties, religious or political zealotry, chemical or biological substances, mass shootings, or a particular incident such as September 11, 2001. Perhaps all of the above. Some may think first of perpetrators of terrorist acts while others may think of reasons given for such acts—and, as a healthcare worker, what comes first to your mind is quite likely all the possible results of terrorist actions.


The Federal Bureau of Investigation (FBI) uses a definition of terrorism that includes “the unlawful use of force and violence against persons or property to intimidate or coerce a government, the civilian population, or any segment thereof, in furtherance of political or social objectives” (28 C.F.R. Section 0.85).

While the use of violence lies at the heart of most definitions of terrorism, arriving at a more nuanced definition often depends on the political, ethnic, or religious perspective of those doing the defining. In addition, terrorism is sometimes categorized as either “domestic” or “international,” referring not to where the terrorist act takes place, but to the origin of the individuals or groups responsible for it. For healthcare professionals facing the medical consequences of a terrorist act, this distinction may not seem especially pertinent.

There is much debate over the motivations for terrorism. Traditionally it has been thought to reflect religious, political, or ideological beliefs, and the targets of attacks to be symbolic in some way. Sparking fear in victims and the wider public is often a motivating element. Recent research suggests motivations may include a personal desire on the part of perpetrators to further their membership in the terrorist community and can be affected by various internal structural issues within terrorist groups (Abrahms & Potter, 2015; Abrahms, 2008).

Terrorist acts have occurred throughout history, but after the Oklahoma City bombing in 1995 and the events of September 11, 2001 in the United States, such behavior became an ongoing element of the public consciousness.

While 9/11 and other events have been planned and executed by large and well-known groups only too willing to claim responsibility, some events suggest that acts of domestic terrorism (ones fitting the FBI definition) are sometimes perpetrated by just one or a few individuals acting not as official members of a group, but claiming to be or appearing to be acting to further a known group’s goals. When those perpetrators die in the act and no charges are filed there may be no official label to be had, but they leave behind enough evidence that it doesn’t seem much of a stretch to call them terrorists.

Terrorism vs. “Mass Shootings”

The Patriot Act defines domestic terrorism as an attempt to “intimidate or coerce a civilian population; to influence the policy of a government by intimidation or coercion; or to affect the conduct of a government by mass destruction, assassination, or kidnapping” (Myre, 2017).

Increasingly, events have occurred that many think of and label as terrorism even though they fall entirely into a definitional and legal gray area. Perhaps most familiar are mass shootings, but a few have been bombings or the weaponizing of vehicles. Some of these include Sandy Hook Elementary School in Newtown, CT, the Aurora Colorado movie theater, and the Wisconsin Sikh temple in 2012; the Boston Marathon in 2013; San Bernardino, CA, and the Charleston, SC, church in 2015; the Orlando, FL, nightclub in 2016; and the Sutherland Springs, TX, church in 2017—sadly, only a small handful of the events of the last twenty years.

Wide access to the Internet means that information about these events travels more quickly, is more widely disseminated, and discussion is more animated and highly charged than ever before. Often these events have obvious things in common with events officially labeled as terrorism, but there are some important distinctions.

As Nevadans became acutely aware in October 2017, with the mass shooting outside the Mandalay Bay Resort in Las Vegas, terrifying events can be perpetrated by a single person using no weapons of mass destruction (chemical, biological, or radiological materials) and with intensely personal reasons and no apparent political motivation. Within the law the label of terrorism is impossible.

These events have sparked debate and calls for change but the issues are complex and there is often little consensus. Citizens are often surprised to find there is no domestic terrorism law that defines these terrifying events as terrorism (Axelrod, 2017; CNN, 2017; Gillin et al., 2017; Myers, 2017: Myre, 2017; Stuart, 2013). Interestingly, Nevada is one of a group of states that do have their own anti-terrorism laws (NRS: Chapter 202) but those laws are seldom invoked (Myre, 2017) and with no one to charge, it’s likely a moot point.

However, one can certainly make the argument that the way in which mass shootings (or bombings or vehicular murders) are perpetrated and the effects they have on victims and near-victims make them terrorism in everything but name. The results can be very similar—mass casualties, surge capacity issues, and widespread fear and panic must all be dealt with by healthcare professionals. Their best defense will always be good preparation.

What Is Being Done?

The U.S. government was already actively working to combat terrorist threats before September 11, 2001 and stepped up its efforts afterwards. For the public and for healthcare workers, education about the proper responses to terrorist activities, along with thorough emergency preparedness, is the best available defense.

In 2003 the Nevada legislature passed Assembly Bill 250, which mandates training for nurses and other healthcare professionals to ensure they have a basic knowledge of potential terrorist threats and how to respond to them.

As noted, the effects of terrorist acts are often not only physical; fear may loom large among citizens, not only among those at the actual site of the attack but also among others much farther away. Healthcare workers need to be prepared to address this fear, even in patients who have sustained little or no physical injury. In addition, psychological effects are recognized consequences of certain types of injuries and will be discussed in the sections that follow.

Analysis of these events and responses to them have resulted in a large body of useful information in the form of resources for individuals and organizations seeking to educate and prepare themselves. The changing nature of the Internet means that some of these resources may come and go, but websites maintained by the Department of Homeland Security (DHS), the Department of Health and Human Services (DHHS), and the CDC remain up-to-date and valuable resources for individuals and institutions.

The State of Nevada has recently restructured its health department and redesigned and updated its corresponding websites and resource links. Contact information and links to both state and federal resources appear at the end of this course.

WMD and Terrorism

Weapons of Mass Destruction

Weapons of mass destruction (WMD) is a term that has become increasingly familiar through its use in the media. Not everyone means precisely the same thing when they use the term, but the definition used by the U.S. military may be the simplest and most generally understood. WMD are:

. . . chemical, biological, radiological, or nuclear weapons capable of a high order of destruction or causing mass casualties (DOD, 2017).

The possibility that terrorists might resort to the use of WMD is of grave concern. The four types of WMD vary in their ability to cause damage, in their ease of production and use, in the kinds of physical and human damage they can be expected to cause, and in their likelihood of use by terrorist organizations.

All four types of WMD offer advantages and obstacles to those who would create and use them. Some require a certain level of skill, others require access to controlled or illegal substances, and still others require significant capital outlay and/or the cooperation of people in positions of security or power. Some weapons could produce significant damage and high death tolls, while the greatest effects of others would be widespread panic and expensive cleanup operations.

Bioterrorism and Chemical Terrorism

The Centers for Disease Control and Prevention (CDC) define bioterrorism as:

. . . biological agents (microbes or toxins) used as weapons to further personal or political agendas. Acts of bioterrorism range from a single exposure directed at an individual by another individual to government-sponsored biological warfare resulting in mass casualties. Bioterrorism differs from other methods of terrorism in that the materials needed to make an effective biological agent are readily available, require little specialized knowledge and are inexpensive to produce (CDC, 2017).

According to the CDC:

A chemical emergency occurs when a hazardous chemical has been released and the release has the potential for harming people’s health. Chemical releases can be unintentional, as in the case of an industrial accident, or intentional, as in the case of a terrorist attack (CDC, 2016).

Some chemicals that are hazardous have been developed by military organizations for use in warfare beginning in World War I. Examples are nerve agents such as sarin and VX, mustards such as sulfur mustards and nitrogen mustards, and choking agents such as phosgene. It might be possible for terrorists to get these chemical warfare agents and use them to harm people (CDC, 2016).

Since the world wars, there has been research and stockpiling of chemicals by many countries, but mutual deterrence has generally prevailed. In 1997 the United States ratified the Chemical Weapons Convention Treaty (CWC), agreeing to destroy any remaining stockpiles of chemical warfare agents no later than April 29, 2012 (CDC, 2016a). One hundred ninety-two countries have signed all or elements of the CWC, which not only requires destruction of chemical weapons but prohibits, among other things, developing, producing, acquiring, stockpiling, and transferring of these weapons (NTI, 2017).

One country that has not signed the CWC is Syria, and in 2013 Syrian president Bashar al-Assad did use chemical weapons against Syrian citizens who were rebelling against his autocratic government.

Many hazardous chemicals are used in industry (eg, chlorine, ammonia, and benzene). Others are found in nature (eg, poisonous plants). Some could be made from everyday items such as household cleaners. These types of hazardous chemicals also could be obtained and used to harm people, or they could be accidentally released (CDC, 2016).

The techniques for making destructive chemical weapons are well understood and the necessary equipment is commonly available. Once made, these weapons can be easily concealed. In 1995 a Japanese cult group known as Aum Shinrikyo made and dispersed the nerve agent sarin several times in the Tokyo subway, killing 17 people and sending 5,500 to the hospital. These incidents made it clear that even small groups could manage the manufacture and dispersal of deadly chemical weapons (NTI, 2015b,e).

Chemical and Biological Weapons

Chemical weapons use the toxic properties of chemicals to cause harm, up to and including death. Only a relatively small amount of a chemical agent is needed to produce significant physical and psychological effects. Historically, chemical weapons have been the most widely used and proliferated type of WMD, but they receive far less attention than do biological and nuclear weapons (NTI, 2015b,e).

Biological weapons utilize microorganisms and natural toxins to produce disease in humans, animals, or plants, and “gram-for-gram, . . . are the deadliest weapons ever produced.” Derived from a variety of sources, these compounds, when paired with a delivery system, become weapons. The potential danger of a given weapon is measured by its lethality—how effectively it kills; its infectivity—how easily it spreads; and its virulence—how likely it is to cause disease. Other important considerations include how easily is it dispersed, whether it can be treated medically, whether there is a vaccine, what dose is needed to cause disease, and the compound’s stability (NTI, 2015a,e).

Chemical and biological weapons are financially and logistically easier to acquire than are radiologic or nuclear weapons. They will cause more casualties and have a greater psychological impact than conventional weapons, but cause less destruction than devices involving radiation. Chemical weapons are somewhat easier than other weapons for terrorist groups (or even individuals) to manufacture because the manufacturing knowledge is readily available, many precursor chemicals have legitimate uses and are thus legally available, there is poor security around these chemicals in some countries, and small chemical manufacturing equipment is commonly available.

Radiologic and Nuclear Weapons

Radiologic and nuclear weapons rely on the same sources for damage—explosive power and radiation—but there is a distinction in their forms. In addition, true nuclear weapons produce tremendous heat, which can cause burns and start fires. In the last fifty years, most radiation injuries have been the result of accidents; however, the intentional deployment of a nuclear or radiologic device is a potential terrorist threat.

Modern nuclear threats can be divided into five general categories:

  • An attack on nuclear power plants
  • A malevolent act using simple radiologic devices
  • Terrorist use of a radiologic dispersal device
  • Detonation of an improvised nuclear device
  • Detonation of a sophisticated nuclear weapon (Waselenko et al., 2004)

Both radiologic and nuclear devices can damage and contaminate. Incidents involving simple devices like Radiation Exposure Devices (REDs) and Radiologic Dispersal Devices (RDDs)—any device that causes intentional dissemination of radioactive material without a nuclear detonation—would probably cause a limited number of casualties; however, those involving Improvised Nuclear Devices (INDs) and small nuclear weapons would result in mass casualties (ORISE, 2017; Waselenko et al., 2004; CISAC, 2002).

Radiologic Dispersal Devices (RDD)—commonly known as “dirty bombs”—are seen as more likely to be used by terrorists. These devices require little more skill than is needed to make a conventional bomb and their components are easier to acquire. RDDs utilize conventional explosives to disperse a radioactive material packaged in the device, as opposed to a nuclear device, which creates radiation with its explosion.

While it is unlikely that many people would die from radiation poisoning as a result of the explosion of an RDD, there would be some deaths and injuries and the costs of cleanup could be considerable. These devices are attractive to some groups because they are relatively easy to create, and they will not generally do a great deal of damage, but they will play on the heightened fear of radiation among the general public to cause widespread panic and disruption, which is often a group’s real goal. Because of this, public education and good response preparation are important counter measures (CISAC, 2002; NTI, 2015c,d,e; ORISE, 2017).

Nuclear weapons present significantly higher obstacles in terms of the skill needed to produce them and the financial and logistical support needed to acquire materials, prepare the devices, and transport them (Weiss, 2015). However, the potential for damage, injuries, and death is much higher because they are significantly more powerful weapons.

Chemical Weapons

Chemical weapons agents are classified as either nonpersistent or persistent. Nonpersistent agents dissipate within a few hours and are most threatening to the lungs. Persistent agents may take up to one month to dissipate if they have been deposited on soil, vegetation, or objects. They are most threatening to the skin.

Scientists often categorize hazardous chemicals by the type of chemical or by the effects a chemical would have on people exposed to it. The categories/types used by CDC are as follows:


Poisons that come from plants or animals

  • Abrin, Brevetoxin, Colchicine, Digitalis, Nicotine, Ricin, Saxitoxin, Strychnine, Tetrodotoxin, Trichothecene

Blister Agents/Vesicants

Chemicals that severely blister the eyes, respiratory tract, and skin on contact

  • Mustards
    • Mustard gas (H) (sulfur mustard)
    • Mustard/lewisite (HL)
    • Nitrogen mustard (HN-1, HN-2, HN-3)
    • Sesqui mustard
    • Sulfur mustard (H) (mustard gas)
  • Lewisites/chloroarsine agents
    • Lewisite (L, L-1, L-2, L-3)
    • Mustard/lewisite (HL)
  • Phosgene oxime (CX)

Blood Agents

Poisons that affect the body by being absorbed into the blood

  • Arsine (SA)
  • Carbon Monoxide
  • Cyanide
    • Cyanogen chloride (CK)
    • Hydrogen cyanide (AC)
    • Potassium cyanide (KCN)
    • Sodium cyanide (NaCN)
  • Sodium monofluoroacetate (compound 1080)

Caustics (Acids)

Chemicals that burn or corrode people’s skin, eyes, and mucus membranes (lining of the nose, mouth, throat, and lungs) on contact

  • Hydrofluoric acid (hydrogen fluoride)
  • Hydrogen chloride

Choking/Lung/Pulmonary Agents

Chemicals that cause severe irritation or swelling of the respiratory tract (lining of the nose, throat, and lungs)

  • Ammonia
  • Bromine (CA)
  • Chlorine (CL)
  • Hydrogen chloride
  • Methyl bromide
  • Methyl isocyanate
  • Osmium tetroxide
  • Phosgene
    • Diphosgene (DP)
    • Phosgene (CG)
  • Phosphine
  • Phosphorus, elemental, white or yellow
  • Sulfuryl fluoride

Incapacitating Agents

Drugs that make people unable to think clearly or that cause an altered state of consciousness (possibly unconsciousness)

  • BZ
  • Fentanyls and other opioids

Long-Acting Anticoagulants

Poisons that prevent blood from clotting properly, which can lead to uncontrolled bleeding

  • Super warfarin


Agents that consist of metallic poisons

  • Arsenic
  • Barium
  • Mercury
  • Thallium

Nerve Agents

Highly poisonous chemicals that work by preventing the nervous system from working properly

  • G agents
    • Sarin (GB)
    • Soman (GD)
    • Tabun (GA)
  • V agents
    • VX

Organic Solvents

Agents that damage the tissues of living things by dissolving fats and oils

  • Benzene

Riot Control Agents/Tear Gas

Highly irritating agents normally used by law enforcement for crowd control or by individuals for protection (eg, mace)

  • Bromobenzylcyanide (CA)
  • Chloroacetophenone (CN)
  • Chlorobenzylidenemalononitrile (CS)
  • Chloropicrin (PS)
  • Dibenzoxazepine (CR)

Toxic Alcohols

Poisonous alcohols that can damage the heart, kidneys, and nervous system

  • Ethylene glycol

Vomiting Agents

Chemicals that cause nausea and vomiting

  • Adamsite (DM) (CDC, 2016b)

Covert Chemical Release

Since September 11, 2001, concern has increased about potential terrorist attacks involving the use of chemical agents. In addition, cases since then involving intentional or inadvertent contamination of food with chemicals highlighted the need for healthcare providers and public health officials to be alert for patients in their communities who have signs and symptoms consistent with chemical exposures (CDC, 2003).

Intentional release of chemical agents may be an overt event, one whose nature reveals itself, such as release of a nerve agent in a subway or a large explosion of a chemical container. On the other hand, a chemical release might be a covert event, an unrecognized release in which the presence of sick people could be the first sign of an exposure; this could include deliberate contamination of food, water, or a consumer product.

To increase the likelihood that healthcare providers recognize a chemical release–related illness, and that public health authorities will implement the appropriate emergency response and public health actions, the CDC has identified examples of chemical-induced illness (see table below under “Identifying Chemical Agents”) and created appropriate guidance for healthcare providers and public health personnel (CDC, 2003).

The CDC recognizes that the covert release of a chemical agent might not be easily identified, for at least five reasons:

  • Symptoms of exposure to some chemical agents (eg, ricin) might be similar to those of common diseases (eg, gastroenteritis).
  • Immediate symptoms of certain chemical exposures might be nonexistent or mild despite the risk for long-term effects (eg, neurocognitive impairment from dimethyl mercury, teratogenicity from isotretinoin, or cancer from aflatoxin).
  • Exposure to contaminated food, water, or consumer products might result in reports of illness to healthcare providers over a long period and in various locations.
  • People exposed to two or more agents might have symptoms not suggestive of any one chemical agent (ie, a mixed clinical presentation).
  • Healthcare providers might be less familiar with clinical presentations suggesting exposure to chemical agents than they are with illnesses that are treated frequently (CDC, 2003).

Epidemiologic Clues

Identifying a covert release of a chemical agent may depend on alert healthcare professionals as they begin to see victims of the release. First receivers (eg, hospital-based emergency staff), may be in the best position to observe epidemiologic clues that suggest such a release. These clues include:

  1. An unusual increase in the number of patients seeking care for potential chemical release–related illness
  2. Unexplained deaths among young or healthy persons
  3. Emission of unexplained odors by patients
  4. Clusters of illness in persons who have common characteristics, such as drinking water from the same source
  5. Rapid onset of symptoms after an exposure to a potentially contaminated medium (eg, parasthesias and vomiting within minutes of eating a meal)
  6. Unexplained death of plants, fish, or animals (domestic or wild)
  7. A syndrome (ie, a constellation of clinical signs and symptoms in patients) suggesting a disease associated commonly with a known chemical exposure (eg, neurologic signs or pinpoint pupils in eyes of patients with a gastroenteritis-like syndrome or acidosis in patients with altered mental status) (CDC, 2003)

Identifying Chemical Agents

Because various chemical agents could be used as covert weapons, the actual clinical syndrome varies depending on the type of agent, the amount and concentration of the chemical, and the route of the exposure. However, some clinical presentations may be more common with a covert chemical release. Certain syndromes are associated with groups of chemical agents with similar toxic properties that have been used previously, have high toxicity, or are easily available (see table) (CDC, 2003).


*Not intended as a complete differential diagnosis for each syndrome or as a list of all chemicals that might be used in a covert chemical release.
**Potential agents for a covert chemical release based on historic use (ie, intentional or inadvertent use), high toxicity, and/or ease of availability.
***Unreliable sign.
Source: CDC, 2003.

Clinical Syndromes and Potential Chemical Etiologies*


Clinical syndrome

Potential chemical etiology

Cholinergic crisis

  • Salivation, diarrhea, lacrimation, bronchorrhea, diaphoresis, and/or urination
  • Miosis, fasciculations, weakness, bradycardia or tachycardia, hypotension or hypertension, altered mental status, and/or seizures
  • Nicotine
  • Organophosphate insecticides**—decreased acetylcholinesterase activity
  • Carbamate insecticides
  • Medicinal carbamates (eg, physostigmine)

Generalized muscle rigidity

Seizure-like, generalized muscle contractions or painful spasms (neck and limbs) and, usually, tachycardia and hypertension

Strychnine—intact sensorium

Oropharyngeal pain and ulcerations

Lip, mouth, and pharyngeal ulcerations and burning pain

  • araquat**—dyspnea and hemoptysis secondary to pulmonary edema or hemorrhage; can progress to pulmonary fibrosis over days to weeks
  • Diquat
  • Caustics (acids, alkalis)
  • Inorganic mercuric salts
  • Mustards (sulfur)

Cellular hypoxia

  • Mild: nausea, vomiting, and headache
  • Severe: altered mental status, dyspnea, hypotension, seizures, and metabolic acidosis
  • Cyanide** (hydrogen cyanide gas, sodium cyanide)—bitter almond odor
  • Sodium monofluoroacetate (SMFA)**—hypocalcemia or hypokalemia
  • Carbon monoxide
  • Hydrogen sulfide
  • Sodium azide
  • Methemoglobin-causing agents

Peripheral neuropathy and/or neurocognitive effects

  • Peripheral neuropathy signs and symptoms: muscle weakness and atrophy, “glove and stocking” sensory loss, and depressed or absent deep-tendon reflexes
  • Neurocognitive effects: memory loss, delirium, ataxia, and/or encephalopathy
  • Mercury (organic)**—visual disturbances, paresthesias, and/or ataxia
  • Arsenic (inorganic)**—delirium and/or peripheral neuropathy
  • Thallium—delirium and/or peripheral neuropathy
  • Lead—encephalopathy
  • Acrylamide—encephalopathy and/or peripheral neuropathy

Severe gastrointestinal illness, dehydration

Abdominal pain, vomiting, profuse diarrhea (possibly bloody), and hypotension, possibly followed by multisystem organ failure

  • Arsenic**
  • Ricin**—inhalation an additional route of exposure; severe respiratory illness possible
  • Colchicine
  • Barium—hypokalemia common


As noted above, it is likely that a covert chemical release would be first recognized by healthcare providers, public health agencies, and poison control centers as they become aware of patterns while assessing illness and treating patients. Familiarity of healthcare professionals with the general characteristics of a covert chemical release, plus recognition of epidemiologic clues and related clinical syndromes, could reduce morbidity and mortality as these workers implement the appropriate emergency response.

Public health agencies and healthcare providers might render the most appropriate, timely, and clinically relevant treatment possible by using treatment modalities based on syndromic categories (eg, burns, respiratory depression, neurologic damage, shock). Because of the hundreds of new chemicals introduced globally each month, it is more pragmatic to treat exposed persons by clinical syndrome rather than specific agent (CDC, 2003; CDC, 2000).

Recognizing Specific Chemical Agents

The Centers for Disease Control and Prevention (CDC) provide many reference materials for recognizing and treating the effects of all types of chemical compounds. These include “reference cards” for dozens of individual chemical compounds that outline essential information for emergency and hospital personnel, including the type of personal protective clothing and equipment (PPE) needed when treating victims. While PPE is necessary for treating virtually anyone who has been exposed to a chemical agent, specifics vary according to the agent involved. It is critical to have this information on hand and for staff to be trained to consult it.

Following are the CDC guidelines for two of the common categories of chemical agents—vesicants and nerve agents. These guidelines provide information on recognizing signs and symptoms, initial treatment, and alternative diagnoses. Remember that the details will differ for other agents and you should always know how to access reference materials quickly at your facility.

Vesicant (Blister Agent) Poisoning

Vesicants, also referred to as “blister agents,” were the most commonly used chemical warfare agents during World War I. Likely routes of exposure are inhalation, dermal contact, and ocular contact. Vesicants are highly reactive chemicals that combine with proteins, DNA, and other cellular components to result in cellular changes immediately after exposure.

Depending on the vesicant, clinical effects may occur immediately (as with phosgene oxime, lewisite) or may be delayed for 2 to 24 hours (as with mustards). Following exposure, the most commonly encountered clinical effects include dermal (skin erythema, blistering), respiratory (pharyngitis, cough, dyspnea), ocular (conjunctivitis, burns), and gastrointestinal (nausea, vomiting).

The amount and route of exposure to the vesicant, the type of vesicant, and the premorbid condition of the person exposed contribute to the time of onset and the severity of illness. For example, ingestion of a vesicant leads to gastrointestinal symptoms more prominent than those that would result from inhalation exposure to the same dose and type of vesicant (CDC, 2013ca).

Signs and Symptoms

The following is a more comprehensive list of signs and symptoms that may be encountered in a person exposed to a vesicant. Signs and symptoms are not listed in order of presentation or specificity. Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease.

Respiratory signs and symptoms include:

  • Chest tightness
  • Clear rhinorrhea
  • Cough
  • Dyspnea (shortness of breath)
  • Hemoptysis
  • Nasal irritation/pain
  • Sore throat
  • Tachypnea

Dermal signs and symptoms include:

  • Blisters (within 1 hour with phosgene oxime, delayed for 2 to 12 hours with lewisite, delayed for 2 to 24 hours with mustards)
  • Erythema (immediate with lewisite and phosgene oxime, may be delayed for 2 to 24 hours with mustards)
  • Immediate blanching (phosgene oxime)
  • Itching
  • Necrosis and eschar (over a period of 7 to 10 days)

Ocular signs and symptoms include:

  • Blindness
  • Blurred vision
  • Corneal ulceration
  • Conjunctivitis
  • Eyelid edema
  • Eye pain/burning
  • Lacrimation
  • Photophobia

Cardiovascular signs include:

  • Atrioventricular block and cardiac arrest (with high-dose exposure)
  • Hypotension (with high-dose exposure to lewisite)

Gastrointestinal signs and symptoms (prominent if ingestion is a route of exposure) include:

  • Abdominal pain
  • Diarrhea (sometimes bloody)
  • Hematemesis
  • Nausea and vomiting

Central nervous system signs and symptoms (with exposure to high doses) include:

  • Ataxia
  • Coma
  • Convulsions
  • Tremors

Hematologic signs and symptoms:

  • Anemia
  • Bleeding/hemorrhage
  • Bone marrow suppression
  • Increased susceptibility to infection
  • Leukocytopenia
  • Thrombocytopenia (CDC, 2013ca)
Laboratory Findings

Although it is a nonspecific finding, leukopenia can indicate vesicant exposure. It usually begins 3 to 5 days after exposure. With a white blood cell count <500, the prognosis is poor.

Differential Diagnosis
  • Barbiturates
  • Bullous pemphigoid
  • Chemotherapeutic agents
  • Carbon monoxide
  • Other chemical burns (eg, with strong acids, bases, corrosives)
  • Pemphigus vulgaris
  • Stevens-Johnson syndrome
  • Staphylococcus scalded skin syndrome
  • Toxic epidermal necrolysis

Note: The actual clinical manifestations of a vesicant exposure may be more variable than the syndrome described above (CDC, 2013ca).

Nerve Agents and Organophosphate (OP) Pesticide Poisoning

Nerve agents are chemical warfare agents that have the same mechanism of action as organophosphate (OP) pesticides. They are potent inhibitors of acetylcholinesterase. Inhibition of acetylcholinesterase leads to an accumulation of acetylcholine in the central and peripheral nervous system. Excess acetylcholine produces a predictable cholinergic syndrome consisting of copious respiratory and oral secretions, diarrhea and vomiting, sweating, altered mental status, autonomic instability, and generalized weakness that can progress to paralysis and respiratory arrest.

The amount and route of exposure to the nerve agent or OP pesticide, the type of nerve agent or pesticide, and the premorbid condition of the exposed person contribute to the time of onset and the severity of illness. For example, inhalation of a nerve agent or an OP pesticide leads to a quicker onset of poisoning with more severe symptoms than dermal exposure, given the same amount of agent (CDC, 2013cb).

Signs and Symptoms

The following are more comprehensive lists of signs and symptoms that may be encountered in a person exposed to a nerve agent or OP pesticide. Signs and symptoms are not listed in order of presentation or specificity. Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease.

Central nervous system signs and symptoms include:

  • Miosis (unilateral or bilateral)
  • Headache
  • Restlessness
  • Convulsions
  • Loss of consciousness
  • Coma

Respiratory signs and symptoms include:

  • Rhinorrhea (perfuse watery runny nose)
  • Bronchorrhea (excessive bronchial secretions)
  • Wheezing
  • Dyspnea (shortness of breath)
  • Chest tightness
  • Hyperpnea (increased respiratory rate/depth)—early
  • Bradypnea (decreased respiratory rate)—late

Cardiovascular signs include:

  • Tachycardia (increased heart rate)—early
  • Hypertension (high blood pressure)—early
  • Bradycardia (decreased heart rate)—late
  • Hypotension (low blood pressure)—late
  • Arrhythmias Dysrhythmias (prolonged QT on EKG, ventricular tachycardia)

Gastrointestinal signs and symptoms include:

  • Abdominal pain
  • Nausea and vomiting
  • Diarrhea
  • Urinary incontinence, frequency

Musculoskeletal signs and symptoms include:

  • Weakness (may progress to paralysis)
  • Fasciculations (local or generalized)

Skin and mucous membrane signs and symptoms include:

  • Profuse sweating (local or generalized)
  • Lacrimation (tear formation)
  • Conjunctival injection
Laboratory Findings
  • Decreased plasma or red blood cell (RBC) cholinesterase activity.


  • Wide normal range for enzyme activity makes interpretation difficult without a baseline measurement.
  • Cholinesterase activity correlates poorly with severity of local effects after vapor exposures.
  • Plasma or RBC cholinesterase may be disproportionately inhibited depending on the particular nerve agent, amount of exposure, and time interval since exposure.

Interpreting cholinesterase activity:

Plasma cholinesterase

  • Usually declines faster than RBC cholinesterase
  • Is easier to assay than RBC cholinesterase
  • Regenerates faster than RBC cholinesterase
  • May have a day-to-day variation in enzyme activity as high as 20%
  • Is less specific than RBC cholinesterase
  • Can show false depression from liver disease, malnutrition, pregnancy, genetic deficiency, or drugs (eg, codeine, morphine, cocaine, succinylcholine)

Red blood cell cholinesterase

  • Is a better reflection of CNS cholinesterase activity
  • Is more specific test than plasma cholinesterase
  • May have a day-to-day variation in enzyme activity as high as 10%
  • Can show false depression from antimalarial therapy or pernicious anemia
Differential Diagnosis
  • Carbamate insecticides
  • Medicinal carbamates (eg, pyridostigmine, neostigmine, physostigmine)
  • Cholinomimetic compounds (eg, pilocarpine, methacholine, bethanechol)
  • Nicotine alkaloids (eg, nicotine, coniine)
  • Muscarine-containing mushrooms
  • Neuromuscular blocking drugs (eg, atracurium, vecuronium)

Note: The actual clinical manifestations of an exposure to a nerve agent or an OP pesticide may be more variable than the syndrome described in this document (CDC, 2013cb).

Biological Weapons

From a scientific and medical perspective, bioterrorism—using biological weapons to produce disease in humans—can be viewed as a variation of the problem of emerging infectious diseases, the only difference being that increased virulence or intentional release are deliberate acts. The United States public health system and primary healthcare providers must be prepared to address various biological agents, including pathogens that are rarely seen in this country.

Covert vs. Overt Bioterrorism

As with chemical agents, the intentional release of biological agents can be either covert or overt. A covert release is unannounced and hidden, and may go unnoticed for days or even weeks. The presence of ill individuals may be the first sign of a release, and those infected may have inadvertently infected others. An infected person may seek medical care anywhere within the healthcare system, possibly at a distance from the release area.

An overt release is immediately apparent and may even be announced. In an overt release, the healthcare system and public health officials may be overwhelmed by requests for information and treatment. Hospitals, clinics, emergency responders, and communication systems will be pressed into immediate service. An overt release has the potential to cause widespread panic.

Whether the release is covert or overt, healthcare providers should be alert to illness patterns and diagnostic clues that indicate an unusual infectious disease outbreak that could be associated with intentional release of a biological agent. In addition, they should watch for increases in unexpected or unexplained illnesses and know how to activate the public health response system if an outbreak is suspected (CDC, 2001). Well-trained and educated first responders, first receivers, and public health personnel are essential to an organized and successful response.

Improving Response to Biologically Induced Illness

Healthcare providers, clinical laboratory personnel, infection control professionals, and public health departments play critical and complementary roles in the recognition and response to illness caused by the intentional release of biological agents. Syndrome descriptions, epidemiologic clues, and laboratory recommendations provide basic guidance that can improve recognition of these events (CDC, 2001).

Since 9/11, state and local health departments have initiated activities to improve recognition, reporting, and response, ranging from enhancing communications to conducting special surveillance projects. This includes active tracking for changes in the number of hospital admissions, emergency department visits, and occurrence of specific syndromes. Bioterrorism preparedness activities and work with emerging infectious diseases have helped public health agencies prepare for the intentional release of a biological agent (CDC, 2001). The CDC’s Emergency Preparedness and Response website has links to and information on the various tools available, as well as other resources.

Recognizing Clinical Syndromes

Work continues on syndromic surveillance projects and the CDC maintains current data on this research. The term syndromic surveillance means watching for health-related data that signal sufficient probability of a case or an outbreak to warrant further public health response. Historically, syndromic surveillance was used in investigating potential cases, but its utility for detecting outbreaks associated with bioterrorism is increasingly being explored by public health officials. Technology changes and the plethora of programs and data have also affected these efforts (CDC, 2004b, 2012; Dembek et al., 2004). (See also the CDC resource website at:

The release of a biological agent may not have an immediate impact because of the delay between exposure and onset of illness, and because outbreaks associated with intentional releases may resemble naturally occurring ones. Nevertheless, healthcare workers should be familiar with indications of intentional release of a biological agent and know when, and to whom, to report a suspected outbreak.

These indications include unusual clustering of illness, patients presenting with clinical signs and symptoms that suggest an infectious disease outbreak, unusual age distribution for common diseases, and a large number of cases of acute flaccid paralysis with prominent bulbar palsies, which is suggestive of a release of botulinum toxin (CDC, 2001).


Epidemiologic Clues That May Signal a Covert Bioterrorism Attack

  • Large number of ill persons with similar disease or syndrome
  • Large number of unexplained disease, syndrome or deaths
  • Unusual illness in a population
  • Higher morbidity and mortality than expected with a common disease or syndrome
  • Failure of a common disease to respond to usual therapy
  • Single case of disease caused by an uncommon agent
  • Multiple unusual or unexplained disease entities coexisting in the same patient without other explanation
  • Disease with an unusual geographic or seasonal distribution
  • Multiple atypical presentations of disease agents
  • Similar genetic type among agents isolated from temporally or spatially distinct sources
  • Unusual, atypical, genetically engineered, or antiquated strain of agent
  • Endemic disease with unexplained increase in incidence
  • Simultaneous clusters of similar illness in non-contiguous areas, domestic or foreign
  • Atypical aerosol, food, or water transmission
  • Ill people presenting near the same time
  • Deaths or illness among animals that precedes or accompanies illness or death in humans
  • No illness

Source: CDC, 2001.


As noted earlier, a variety of factors affect the potential public health impact of an intentionally released biological agent:

  • Lethality—how effectively it kills
  • Infectivity—how easily it spreads
  • Virulence—how likely it is to cause disease
  • How easily it is dispersed
  • Availability of medical treatment and/or vaccine
  • Dosage needed to cause disease
  • Stability of the compound (NTI, 2015a,e)

It may be difficult to pinpoint the time and location of a biological agent’s release because of the variation in incubation period among organisms. Some diseases show a rapid onset of symptoms and early treatment is critical. For example, plague has a rapid onset and is potentially fatal within 12 to 24 hours if untreated; botulism toxin also has a rapid onset and requires immediate supportive treatment. On the other hand, smallpox can be treated effectively by vaccination within 2 to 3 days of symptom onset. But smallpox, like plague, is highly contagious and has the potential to cause widespread panic, and in the case of smallpox, which is believed to have been eradicated, not enough vaccine exists should a widespread outbreak occur. Conversely, plague and anthrax, despite their potential for causing serious illness and death, are effectively treated with antibiotics.

Categories of Diseases and Biological Agents

Bioterrorism agents can be separated into three categories, depending on how easily they can be spread and the severity of illness or death they cause. Category A agents are considered the highest risk and Category C agents are those that are considered emerging threats for disease (CDC, 2017a).

Category A Diseases or Agents

Category A diseases or agents are high priority and include organisms that pose the highest risk to the public and national security because they:

  • Are easily spread or transmitted from person to person
  • Result in high mortality rates and have the potential for major public health impact
  • May cause public panic and social disruption
  • Require special action for public health preparedness (CDC, 2017a)

Category A bioterrorism agents are:

  • Anthrax (Bacillus anthracis)
  • Botulism (Clostridium botulinum toxin)
  • Plague (Yersinia pestis)
  • Smallpox (variola major)
  • Tularemia (Francisella tularensis)
  • Viral hemorrhagic fevers, including
    • Filoviruses (Ebola, Marburg)
    • Arenaviruses (Lassa, Machupo) (CDC, 2017a)

Category B Diseases or Agents

Category B diseases or agents are the second highest priority because they:

  • Are moderately easy to disseminate
  • Result in moderate illness rates and low mortality rates, and
  • Require specific enhancements of CDC’s diagnostic capacity and enhanced disease surveillance (CDC, 2017a)

Category B diseases or agents include:

  • Brucellosis (Brucella species)
  • Epsilon toxin of Clostridium perfringens
  • Food safety threats (Salmonella species, Escherichia coli O157:H7, and Shigella)
  • Glanders (Burkholderia mallei)
  • Melioidosis (Burkholderia pseudomallei)
  • Psittacosis (Chlamydia psittaci)
  • Q fever (Coxiella burnetii)
  • Ricin toxin from Ricinus communis (castor beans)
  • Staphylococcal enterotoxin B
  • Typhus fever (Rickettsia prowazekii)
  • Viral encephalitis (alphaviruses—Venezuelan equine encephalitis, eastern and western equine encephalitis)
  • Water safety threats (Vibrio cholerae, Cryptosporidium parvum) (CDC, 2017a)

Category C Diseases or Agents

Category C diseases or agents are the third highest priority and include emerging pathogens that could be engineered for mass dissemination in the future because they:

  • Are easily available
  • Are easily produced and spread
  • Have potential for high morbidity and mortality rates and major health impact

Agents include emerging infectious diseases such as Nipah virus and hantavirus (CDC, 2017a).

Clinical Features of High-Priority Agents

Four category A diseases have been the focus of the CDC’s efforts to educate the healthcare community about bioterrorism potential: anthrax, botulism, plague, and smallpox. The CDC does not prioritize these agents in any order of importance or likelihood of use. Other agents with bioterrorism potential include those that cause tularemia and viral hemorrhagic fevers (category A), brucellosis, Q fever, viral encephalitis, and disease associated with staphylococcal enterotoxin, category B. Other important category B agents include any organism that threatens the water or food supply.


Anthrax has been recognized as an infectious disease of animals and humans for millennia. Within the United States, animal anthrax is reported in most years, but naturally occurring human anthrax is rare. Worldwide, however, the disease is common in wild and domestic animals and not uncommon among people who interact with animals in agricultural regions of South and Central America, sub-Saharan Africa, central and southwestern Asia, and southern and eastern Europe (Hendricks, et al. [CDC], 2014).

Bacillus anthracis, the causative agent of anthrax, is a nonmotile spore-forming, gram-positive, rod-shaped bacterium. Biodefense experts often place B. anthracis at or near the top of the list for potential threat agents. Inhalation anthrax is particularly deadly, as demonstrated by the 1979 accidental release of B. anthracis from a military microbiology facility in the Sverdlovsk region of Russia; 88% (66/75) of patients reported with inhalation anthrax died. More recently, humans have acquired disease from exposure to spores released purposefully as a bioterrorist weapon and accidentally from naturally occurring sources (Hendricks, et al. [CDC], 2014).

If a bioterrorist attack were to happen, Bacillus anthracis would be one of the biological agents most likely to be used. Biological agents are germs that can sicken or kill people, livestock, or crops. Anthrax is one of the most likely agents to be used because:

  • Anthrax spores are easily found in nature, can be produced in a lab, and can last for a long time in the environment.
  • Anthrax makes a good weapon because it can be released quietly and without anyone knowing. The microscopic spores could be put into powders, sprays, food, and water. Because they are so small, you may not be able to see, smell, or taste them.
  • Anthrax has been used as a weapon before. (CDC, 2014)

Anthrax has been used as a weapon around the world for nearly a century. In 2001 powdered anthrax spores were deliberately put into letters that were mailed through the U.S. postal system. Twenty-two people, including 12 mail handlers, got anthrax, and five of these 22 people died.


image: photo of Daschle letter

A letter sent in 2001 to Senate Majority Leader Tom Daschle contained anthrax powder. Beginning one week after the September 11 attacks, letters containing anthrax spores were mailed to several news media offices and two U.S. Senators, killing five people and infecting 17 others. Source: Wikimedia Commons.


A subset of select agents and toxins have been designated as Tier 1 because these biological agents and toxins present the greatest risk of deliberate misuse with significant potential for mass casualties or devastating effect to the economy, critical infrastructure, or public confidence, and pose a severe threat to public health and safety. Bacillus anthracis is a Tier 1 agent.

An anthrax attack could take many forms. For example, it could be placed in letters and mailed, as was done in 2001, or it could be put into food or water. Anthrax also could be released into the air from a truck, building, or plane. This type of attack would mean the anthrax spores could easily be blown around by the wind or carried on people’s clothes, shoes, and other objects. It only takes a small amount of anthrax to infect a large number of people.

If anthrax spores were released into the air, people could breathe them in and get sick with anthrax. Inhalation anthrax is the most serious form and can kill quickly if not treated immediately. If the attack were not detected by one of the monitoring systems in place in the United States, it might go unnoticed until doctors begin to see unusual patterns of illness among sick people showing up at emergency rooms (CDC, 2014).

There are four clinical forms of anthrax: cutaneous or skin, inhalation or respiratory tract, gastrointestinal, and injection (has occurred in northern Europe but has never been reported in the United States) (CDC, 2017b).

Cutaneous Anthrax

When anthrax spores get into the skin, usually through a cut or scrape, a person can develop cutaneous anthrax. This can happen when a person handles infected animals or contaminated animal products like wool, hides, or hair. Cutaneous anthrax is most common on the head, neck, forearms, and hands. It affects the skin and tissue around the site of infection.

Cutaneous anthrax is the most common form of anthrax infection, and it is also considered to be the least dangerous. Infection usually develops from 1 to 7 days after exposure. Without treatment, up to 20% of people with cutaneous anthrax may die. However, with proper treatment, almost all patients with cutaneous anthrax survive (CDC, 2014a).

Cutaneous anthrax symptoms can include:

  • A group of small blisters or bumps that may itch
  • Swelling can occur around the sore
  • A painless skin sore (ulcer) with a black center that appears after the small blisters or bumps, most often on the face, neck, arms, or hands (CDC, 2014e)
Inhalation Anthrax

When a person breathes in anthrax spores, they can develop inhalation anthrax. People who work in places such as wool mills, slaughterhouses, and tanneries may breathe in the spores when working with infected animals or contaminated animal products from infected animals. Inhalation anthrax starts primarily in the lymph nodes in the chest before spreading throughout the rest of the body, ultimately causing severe breathing problems and shock.

Inhalation anthrax is considered to be the deadliest form of anthrax. Infection usually develops within a week after exposure, but it can take up to 2 months. Without treatment, only about 10% to 15% of patients with inhalation anthrax survive. However, with aggressive treatment, about 55% of patients survive (CDC, 2014b).

Inhalation anthrax symptoms can include:

  • Fever and chills
  • Chest discomfort
  • Shortness of breath
  • Confusion or dizziness
  • Cough
  • Nausea, vomiting, or stomach pains
  • Headache
  • Sweats (often drenching)
  • Extreme tiredness
  • Body aches (CDC, 2014e)
Gastrointestinal Anthrax

When a person eats raw or undercooked meat from an animal infected with anthrax, they can develop gastrointestinal anthrax. Once ingested, anthrax spores can affect the upper gastrointestinal tract (throat and esophagus), stomach, and intestines.

Gastrointestinal anthrax has rarely been reported in the United States. Infection usually develops from 1 to 7 days after exposure. Without treatment, more than half of patients with gastrointestinal anthrax die. However, with proper treatment, 60% of patients survive (CDC, 2014c).

Gastrointestinal anthrax symptoms can include:

  • Fever and chills
  • Swelling of neck or neck glands
  • Sore throat
  • Painful swallowing
  • Hoarseness
  • Nausea and vomiting, especially bloody vomiting
  • Diarrhea or bloody diarrhea
  • Headache
  • Flushing (red face) and red eyes
  • Stomach pain
  • Fainting
  • Swelling of abdomen (stomach) (CDC, 2014e)
Injection Anthrax

Recently, another type of anthrax infection has been identified in heroin-injecting drug users in northern Europe. This type of infection has never been reported in the United States.

Symptoms may be similar to those of cutaneous anthrax, but there may be infection deep under the skin or in the muscle where the drug was injected. Injection anthrax can spread throughout the body faster and be harder to recognize and treat. Lots of other more common bacteria can cause skin and injection site infections, so a skin or injection site infection in a drug user does not necessarily mean the person has anthrax (CDC, 2014d).

Injection anthrax symptoms can include:

  • Fever and chills
  • A group of small blisters or bumps that may itch, appearing where the drug was injected
  • A painless skin sore with a black center that appears after the blisters or bumps
  • Swelling around the sore
  • Abscesses deep under the skin or in the muscle where the drug was injected (CDC, 2014e)


Botulism is a neuroparalytic illness characterized by symmetric, descending flaccid paralysis of motor and autonomic nerves, always beginning with the cranial nerves.

Signs and symptoms in an adult may include:

  • Diplopia (double vision)
  • Blurred vision
  • Ptosis (drooping eyelids)
  • Slurred speech
  • Dysphagia (difficulty swallowing)
  • Dry mouth
  • Muscle weakness

Signs and symptoms in foodborne illness may also include:

  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea

Signs and symptoms in an infant may include:

  • Poor feeding
  • Diminished suckling and crying ability
  • Neck and peripheral weakness (“floppy baby”)
  • Constipation
  • Respiratory failure

If untreated, illness might progress to cause descending paralysis of respiratory muscles, arms, and legs (CDC, 2017c).


Botulism Case Consultation

If you suspect your patient may have botulism, call your state public health department immediately. If there is no answer, contact CDC 24/7 at 770 488 7100.

  • For non-infant cases: State public health officials can reach the CDC clinical emergency botulism service for consultation and antitoxin 24/7 at 770 488 7100. If administered early in the course of illness, antitoxin can prevent progression of illness and shorten its duration.
  • For infant botulism: The Infant Botulism Treatment and Prevention Program at the California Department of Public Health provides consultation 24/7 and can be reached at 510 231 7600.

If clinical consultation with state public health departments and CDC supports botulism, request antitoxin immediately and begin treatment as soon as it is available. Do not wait for laboratory confirmation.

Source: CDC, 2017c.


Etiology and Transmission

Botulism is caused by a potent neurotoxin produced from Clostridium botulinum, and rare strains of C. butyricum and C. baratii, which are anaerobic, spore-forming bacteria.

Transmission differs by type of botulism:

Foodborne botulism occurs when a person ingests botulinum toxin, which leads to illness within a few hours to days. Outbreaks of foodborne botulism have potential to be a public health emergency because the contaminated food may be eaten by other people. A frequent source is home-canned foods prepared in an unsafe manner.

Infant botulism occurs each year in a small number of susceptible infants who harbor C. botulinum in their intestinal tract. It occurs when an infant ingests spores of C. botulinum, which in turn colonize the intestinal tract and produce toxin.

Wound botulism is a rare disease that occurs when wounds infected with C. botulinum secrete the toxin. It occurs more frequently among persons who inject drugs, but has also been seen in cases of traumatic injury, such as motorcycle crashes, and surgeries.

Adult intestinal colonization (also called adult intestinal toxemia) is an even rarer type of botulism. It involves intestinal colonization in a person older than one year of age. In the small number of these cases, most patients had a history of gastrointestinal surgery or illness, such as inflammatory bowel disease, which might have predisposed them to enteric colonization. No other specific risk factors have been identified.

Iatrogenic botulism occurs after an overdose of injected botulinum toxin for cosmetic or medical purposes (CDC, 2017c).

Diagnosis and Testing

Botulism differs from other flaccid paralyses in that it always manifests initially with prominent cranial nerve palsies. It also differs in its invariable descending progression, in its symmetry, and in its absence of sensory nerve dysfunction.

Botulism is frequently misdiagnosed, most often as a polyradiculoneuropathy (Guillain-Barré or Miller-Fisher syndrome), myasthenia gravis, or other diseases of the central nervous system.

Clinical diagnosis of botulism is confirmed by specialized laboratory testing that often requires days to complete. Routine laboratory test results are usually unremarkable (CDC, 2017c).

Initial diagnosis is based on clinical symptoms. Do not wait for laboratory confirmation to begin treatment.

Laboratory confirmation is done by demonstrating the presence of botulinum toxin in serum, stool, or food, or by culturing C. botulinum, C. butyricum, or C. baratii from stool, a wound, or food.

Other tests and laboratory studies to help with clinical diagnosis include:

  • Routine lab tests (CBC, electrolytes, LFTs, urinalysis): generally not helpful in diagnosis as these tests show no characteristic abnormalities
  • Cerebrospinal fluid (CSF) studies: essentially normal, although occasionally a borderline elevation in protein level may be seen
  • Tensilon test: A normal test helps to differentiate botulism from myasthenia gravis; borderline positive tests can occur in botulism.
  • CTs and MRIs: Normal CTs and MRIs help to rule out cerebrovascular accident (CVA). (CDC, 2017c)

Administer botulinum antitoxin or BabyBIG as soon as possible. Antitoxin does not reverse paralysis but arrests its progression. Recovery follows the regeneration of new neuromuscular connections.

Exercise meticulous intensive care, including monitoring of respiratory function and, when required, mechanical ventilation. In more severe cases, ventilator support may be required for weeks to months.

Treatment for wound botulism may also include wound debridement to remove the source of toxin‑producing bacteria and antibiotic therapy (CDC, 2017c).

Infection Control

Medical personnel caring for patients with suspected botulism should use standard precautions. Botulism is not transmitted person-to-person.

Patients with botulism do not need to be isolated (CDC, 2017c).


Death can result from respiratory failure or the consequences of extended paralysis. About 5% of patients die. Recovery takes weeks to months. Those who survive may have fatigue and shortness of breath for years (CDC, 2017c).


In 2015 there were 199 cases of laboratory-confirmed botulism reported to the CDC. Of these, 39 were foodborne, 141 were infant botulism, 15 were cases of wound botulism, and 4 cases were of unknown etiology (CDC, 2017c).

Plague (Yersinia pestis)

Plague is a disease caused by Yersinia pestis (Y. pestis), a bacterium found in rodents and their fleas in many areas around the world (CDC, 2015d).


Bubonic plague is the most common primary manifestation, with a bubo usually occurring in the groin, axilla, or cervical nodes. Buboes are often so painful that patients are generally guarded and have restricted movement in the affected region. The incubation period for bubonic plague is usually 2 to 6 days.

If bubonic plague is untreated, plague bacteria invade the bloodstream and spread rapidly, causing septicemic plague, and if the lungs are seeded, secondary pneumonic plague. Septicemic and pneumonic plague may also be primary manifestations. A person with pneumonic plague may experience high fever, chills, cough, and breathing difficulty and may expel bloody sputum. If pneumonic plague patients are not given specific antibiotic therapy, the disease can progress rapidly to death.

Although the majority of patients with plague present with a bubo, some may have nonspecific symptoms. For example, septicemic plague can present with prominent gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. Additional rare forms of plague include pharyngeal, meningeal, and cutaneous.

Appropriate diagnostic samples include blood cultures, lymph node aspirates if possible, and/or sputum, if indicated. Drug therapy should begin as soon as possible after the laboratory specimens are taken. If plague is suspected, local and state health departments should be notified immediately. If patients have pneumonic signs, they should also be isolated and placed on droplet precautions (CDC, 2015a).

Symptoms and Transmission

Pneumonic plague can be transmitted from person to person; bubonic plague cannot. Pneumonic plague affects the lungs and is transmitted when a person breathes in Y. pestis particles. Bubonic plague is transmitted through the bite of an infected flea or exposure to infected material through a break in the skin (CDC, 2015d).

Plague symptoms depend on how the patient was exposed to the plague bacteria.

Bubonic: Sudden onset of fever, headache, chills, and weakness and one or more swollen, tender, and painful lymph nodes (called buboes). This usually results from the bite of an infected flea.

Septicemic: Fever, chills, extreme weakness, abdominal pain, shock, and possibly bleeding into the skin and other organs. This usually results from bites of infected fleas or from handling an infected animal.

Pneumonic: Fever, headache, weakness, and a rapidly developing pneumonia with shortness of breath, chest pain, cough, and sometimes bloody or watery mucous. Nausea, vomiting, and abdominal pain may also occur. May develop from inhaling infectious droplets or from untreated bubonic or septicemic plague that spreads to the lungs (CDC, 2015a,b,c,d).

Pneumonic Plague as Bioweapon

Yersinia pestis used in an aerosol attack could cause cases of the pneumonic form of plague. One to six days after becoming infected with the bacteria, people would develop pneumonic plague. Once people have the disease, the bacteria can spread to others who have close contact with them. Because of the delay between being exposed to the bacteria and becoming sick, people could travel over a large area before becoming contagious and possibly infecting others. Controlling the disease would then be more difficult. A bioweapon carrying Y. pestis is possible because the bacterium occurs in nature and could be isolated and grown in quantity in a laboratory. Even so, manufacturing an effective weapon using Y. pestis would require advanced knowledge and technology (CDC, 2015d).

National and state public health officials have large supplies of drugs needed in the event of a bioterrorism attack. These supplies can be sent anywhere in the United States within 12 hours (CDC, 2015d).

Smallpox (Variola)

Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980 the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since.

Smallpox research in the United States continues and focuses on the development of vaccines, drugs, and diagnostic tests to protect people against smallpox in the event that it is used as an agent of bioterrorism (CDC, 2016c).

Before smallpox was eradicated, it was a serious infectious disease caused by the variola virus. It was contagious—meaning, it spread from one person to another. People who had smallpox had a fever and a distinctive, progressive skin rash.

Most people with smallpox recovered, but about 3 out of every 10 people with the disease died. Many smallpox survivors have permanent scars over large areas of their body, especially their faces. Some are left blind (CDC, 2016c).

Before smallpox was eradicated, it was mainly spread by direct and fairly prolonged face-to-face contact between people. Smallpox patients became contagious once the first sores appeared in their mouth and throat (early rash stage). They spread the virus when they coughed or sneezed and droplets from their nose or mouth spread to other people. They remained contagious until their last smallpox scab fell off.

These scabs and the fluid found in the patient’s sores also contained the variola virus. The virus can spread through these materials or through the objects contaminated by them, such as bedding or clothing. People who cared for smallpox patients and washed their bedding or clothing had to wear gloves and take care to not get infected.

Rarely, smallpox has spread through the air in enclosed settings, such as a building (airborne route).

Smallpox can be spread by humans only. Scientists have no evidence that smallpox can be spread by insects or animals (CDC, 2016c).

A person with smallpox goes through several stages as the disease progresses. Each stage has its own signs and symptoms.

  • Incubation
  • Initial symptoms
  • Early rash
  • Pustular rash and scabs
  • Scabs fall off
  • No scabs (CDC, 2016c)

There is no proven treatment for smallpox disease, but some antiviral drugs may help treat it or prevent it from getting worse. There also is a vaccine to protect people from smallpox. If there were a smallpox outbreak, health officials would use the smallpox vaccine to control it (CDC, 2016c).


Distribution of Pox Rash

illustration of pox rash distribution in smallpox and chickenpox


Most likely, if smallpox is released into the United States as a bioterrorist attack, public health authorities will learn of it when the first afflicted person goes to a hospital for treatment of an unknown illness. Physicians will examine the person using tools developed by CDC to decide if signs and symptoms are similar to those of smallpox. If they suspect the person has smallpox, they will isolate and care for the person in the hospital so that others do not come in contact with the smallpox virus. The hospital will contact local public health authorities that they have a patient who might have smallpox.

Local public health authorities would then alert public health officials at the state and federal level to help diagnose the disease. If experts confirm the illness is smallpox, then CDC, along with state and local public health authorities, will put into place their plans to respond to a bioterrorist attack with smallpox (CDC, 2016c).

Best Practices for First Receivers

Healthcare workers risk occupational exposures to biological materials when a hospital receives contaminated patients, particularly during mass casualty events. Hospital employees termed first receivers work at a site removed from where the hazardous release occurred. This means that their exposures are limited to the substances transported to the hospital on the skin, hair, clothing, or personal effects of the victims. The location and limited source of contaminants distinguishes first receivers from first responders such as firefighters, law enforcement, and ambulance service personnel, who typically respond to the incident site (OSHA, 2005).

Worst-case scenarios take into account challenges associated with communication, resources, and victims. During mass-casualty emergencies, hospitals can anticipate little or no warning before victims begin arriving. First receivers can anticipate that information regarding the hazardous agents may not be available immediately. Hospitals can also anticipate a large number of self-referred victims (as many as 80% of the total number of victims) and should assume victims will not have been decontaminated prior to arriving at the hospital (OSHA, 2005).

An employee’s role at a facility and the corresponding hazards the employee might encounter dictate the level of training that must be provided to any individual first receiver. Selection of personal protective equipment (PPE) must be based on a hazard assessment that carefully considers both of these factors, along with the steps taken to minimize the extent of the employee’s contact with hazardous substances (OSHA, 2005). Surge capacity, triage, decontamination, security, and disposal of contaminated wastewater must also be addressed.

Surge Capacity

In the event of a mass casualty event, healthcare organizations must be able to increase their services quickly in response to the crisis. This is an organization’s surge capacity, “the ability to expand care capabilities in response to sudden or prolonged demand” (JCAHO, 2003; Kelen, 2008). Staffing levels, education and training, decontamination capabilities, vaccination programs for direct caregivers, volunteer resources, and stockpiling of supplies must be assessed while, in most cases, routine care continues.

Individual personnel on an emergency response team have slightly differing concerns and responsibilities when it comes to surge situations. While surge capacity planning is an administrative level concern, individual healthcare providers should understand the basic concept and the need for guidelines in order to participate effectively in training and any necessary implementation. The CDC’s handbook, Updated in a Moment’s Notice: Surge Capacity in Terrorist Bombings, is available here: (CDC, 2010).

The ability of the organization to “degrade gracefully” must also be considered. A healthcare organization should have a plan to deal with a reduction in services as the number of patients increases. The goal is to engineer and manage failures and thus to avoid “catastrophic failure” (JCAHO, 2003). During a state of emergency, it may be impossible to follow normal practice guidelines. The Joint Commission recommends that hospitals and oversight agencies “provide for waiver of regulatory requirements under conditions of extreme emergency” (JCAHO, 2003).


Pre-decontamination triage serves three purposes:

  • Distinguishes contaminated individuals from other patients arriving at the hospital by identifying symptoms and victim’s proximity to a known chemical release
  • Identifies patients who require immediate stabilization before they enter the decontamination system
  • Identifies injuries or critical pre-hospital treatment materials that will require special handling inside the decontamination system (OSHA, 2005)

Post decontamination triage for medical treatment should occur in the hospital post-decontamination zone after victims are inspected and found to be free of contamination. Some hospitals combine decontamination and initial medical treatment (such as antidotes), which means either the healthcare worker attempts medical triage while wearing PPE (preferred) or the worker is at risk of exposure from victims who have not been adequately decontaminated (OSHA, 2005).

Decontamination Activities

Hospitals must identify spaces that will support decontamination activities (including equipment storage) and ensure that operations can continue in the event that one area of the hospital becomes contaminated. Hospitals planning additions or remodeling projects have a unique opportunity to design spaces appropriately. Other hospitals should use creative planning to identify existing architectural features that they can use to their advantage. Nonambulatory victims can require a substantial proportion of first receivers’ time and efforts, and first receivers are likely to experience the greatest exposure while assisting these victims (OSHA, 2005).

If decontamination is necessary, numerous agencies and organizations recommend a shower time of approximately five minutes for contaminated victims brought to a hospital. Despite the fact that there is no empirical data, operational procedures deem this time to be adequate. Numerous agencies and programs recommend the use of water and a liquid soap with good surfactant properties (such as hand dishwashing detergent) to decontaminate victims during emergencies and for mass casualties involving hazardous substances (OSHA, 2005).

Isolation and Lockdown

Hospitals can use a variety of methods to limit unauthorized access to the emergency department until the victims have been decontaminated. The methods range from a guard at the locked door to sophisticated keycard systems controlled at a central command center. These more complex systems tend to be associated with urban or recently modernized hospitals and are intended for use in any type of disturbance. Hospitals can use these methods if situations suggest that an unruly crowd will force its way into the hospital (OSHA, 2005).


Site security helps maintain order and control traffic around the decontamination facility and the hospital entrances. Security officers might need to control a contaminated individual to prevent other staff from becoming exposed and to protect equipment. Security officers also ensure contaminated victims do not bypass the decontamination hospital or enter the ED without passing inspection. In cases of civil disturbance, properly identified security officers protect the decontamination facility and staff so normal operations can continue (OSHA, 2005).

Personal Protective Equipment

Hospitals should select personal protective equipment (PPE) such as respirators, suits, gloves, and face and eye protection based on a hazard assessment that identifies the hazards to which employees might be exposed. Under OSHA’s Personal Protective Equipment Standard, or the parallel State Plan standards, all employers, including hospitals, must certify in writing that the hazard assessment has been performed. For first-receiver PPE, hospitals may base the hazard assessment on OSHA’s Best Practices document. Hospitals likely to respond to incidents involving a specific hazard should adjust the PPE accordingly (OSHA, 2005).

OSHA’s Personal Protective Equipment Standard also requires that employees be provided with equipment that fits appropriately. Some hospitals assign a set of protective equipment to a specific individual, and that equipment is stored in a container marked with the individual’s name. Other hospitals maintain general supplies of PPE, storing sets of equipment by size. In this case, the packages are clearly marked only with the size. Each first receiver tries on equipment in advance to determine what size group fits best so that, during an emergency, the employee can quickly locate an appropriate PPE set (OSHA, 2005).

Personal protective equipment selection for first receivers has been a topic of extensive discussion. At the root of this discussion is the need for hospitals to provide adequate protection for the reasonably anticipated worst-case scenario, despite having limited information regarding the nature of the substance with which victims may be contaminated. This lack of information challenges hospitals’ abilities to conduct the hazard assessments on which PPE selection must be based (OSHA, 2005).

Infection Control

Heightened awareness by infection control (IC) professionals facilitates recognition of the release of a biological agent. Infection control professionals are involved with many aspects of hospital operations and several departments, and with their counterparts in other hospitals. As a result, they may recognize changing patterns or clusters in a hospital or in a community that might otherwise go unrecognized (CDC, 2001).

Infection control professionals should ensure that hospitals have current telephone numbers for notification of both internal and external contacts and that they are distributed to the appropriate personnel. They should work with clinical microbiology laboratories, on- or off-site, that receive specimens for testing from their facility to ensure that cultures from suspicious cases are evaluated appropriately (CDC, 2001).

Wastewater Management

Wastewater from decontamination showers can contain low-level concentrations of the substance(s) with which victims are contaminated. Given the opportunity to plan for decontamination activities (by designing and installing or purchasing decontamination facilities, developing procedures, and preparing staff), hospitals should consider the management of decontamination shower water as part of their emergency preparedness plan (OSHA, 2005).

Decontaminating Surfaces and Equipment

The hospital emergency management plan should include procedures for cleaning equipment and surfaces during and after an incident. Cleaning should be performed by employees who are properly protected and trained. Items that cannot be decontaminated safely should be processed for appropriate disposal. It is unlikely that portable gear could be adequately decontaminated after an incident involving a persistent or highly toxic agent (OSHA, 2005).

Reporting an Incident of Bioterrorism

In the event of an incident of bioterrorism in your community, you should know what to report and to whom the report should be sent. First reporters should start at the healthcare organization or hospital level by reporting to the department supervisor, laboratory, and infection control department. Then contact the local health/regional departments, which will contact the Nevada State Health Division and the CDC. Successful reporting of a bioterrorism event results from good planning, education, and awareness, as well as regular standardized testing before an occurrence.

In most cases telephone will still be the primary means for immediate reporting because it is direct, rapid, and easy-to-use. There should always be a backup communication plan (eg, cell phones or other means) in case of a telephone system failure. In every institution standards should be established to ensure a reliable and immediate response to notifiable diseases and health conditions.

Nevada Reporting

Nevada Division of Public and Behavioral Health (DPBH)

Main: 775 684 4200

Public Health Emergency: 775 684 5920

Infectious disease reporting: 775 684 5911

Washoe County: 775 328 2447 (24 hr)

Southern Nevada: 702 759 1300, option #2 (24 hr)

Radiological and Nuclear Weapons

Radiation is any form of energy propagated as rays, waves, or energetic particles that travel (radiate) from their source. Radiation can travel through the air or through a material medium (CISAC, 2002).

There are five primary types of radiation:

  • Alpha particles
  • Beta particles
  • Gamma rays
  • X-rays
  • Neutrons (ORISE, 2017)

Radiation types vary in their size, charge, ability to travel, and ability to penetrate objects. These variations affect their uses, their current and future effects, what materials effectively shield against them, the parts of the body they can potentially damage, and the exposure restrictions mandated by the government (ORISE, 2017).

Radioactive materials are composed of atoms that are unstable. An unstable atom gives off its excess energy until it becomes stable. The energy emitted is radiation. The process by which an atom changes from an unstable state to a more stable state by emitting radiation is called radioactive decay or radioactivity (CISAC, 2002).

Radiation is often divided into ionizing and non-ionizing radiation. Radiation that has enough energy to move atoms in a molecule or cause them to vibrate, but not enough to change them chemically, is referred to as non-ionizing radiation. Examples of this kind of radiation are radio waves and visible light (CISAC, 2002).

Radiation that falls within the ionizing radiation range (alpha and beta particles and gamma rays) has enough energy to break the bonds that tie electrons into the atoms or molecules that make up ordinary substances. This is the type that people usually think of as “radiation” when dealing with nuclear dangers. Ironically, this is also the type of radiation that is used for medical treatment and in many manufacturing processes (CISAC, 2002; ORISE, 2015).

Compared with other types of radiation that may be absorbed, ionizing radiation deposits a large amount of energy into a small area. All ionizing radiation is capable, directly or indirectly, of removing electrons from most molecules. This property of ionizing radiation lies at the root of both its usefulness and its dangers (CISAC, 2002).

Radiation cannot be detected by the human senses. A radiologic survey conducted with specialized equipment is the only way to confirm the presence of radiation. If a terrorist event involves the use of radioactive material, both patient exposure and contamination must be assessed.

Exposure occurs when a person is near a radiation source. People exposed to a source of radiation can suffer radiation illness if the dose is high enough, but they do not become radioactive. For example, an x-ray machine is a source of radiation exposure, yet a person does not become radioactive or pose a risk to others following a chest x-ray (CDC, 2014g).

Measuring Radiation

When scientists measure radiation, they use different terms depending on whether they are discussing radiation coming from a radioactive source, the radiation dose absorbed by a person, or the risk that a person will suffer health effects (biological risk) from exposure.

Most scientists in the international community measure radiation using the Système International d’Unités (SI), a uniform system of weights and measures that evolved from the metric system. In the United States, however, the conventional system of measurement is still widely used.

Different units of measure are chosen depending on what aspect of radiation is being measured. For example, the amount of radiation being given off, or emitted, by a radioactive material is measured using the conventional unit curie (Ci), named for the famed scientist Marie Curie, or the SI unit becquerel (Bq).

The radiation dose absorbed by a person (the amount of energy deposited in human tissue by radiation) is measured using the conventional unit rad or the SI unit gray (Gy). The biologic risk of exposure to radiation (the risk that a person will suffer health effects from an exposure to radiation) is measured using the conventional unit rem or the SI unit sievert (Sv) (CDC, 2014i).

Types of Radiation Injury

The only non-test deployment of nuclear weapons was the 1945 dropping of the atomic bombs on Hiroshima and Nagasaki, Japan, near the end of World War II. Those at the center of impact were killed immediately by thermal and shock forces as well as intense radiation poisoning. Others at varying distances from the bomb’s center were injured and died later. Still others are alive today, but many of them have suffered from the latent effects of radiation exposure. Patterns of aftereffects are known, as are the patterns of radiation illness and injury that follow closely upon exposure. Understanding these patterns will aid in diagnosis and treatment of radiation-induced injury or illness.

Radioactive contamination and radiation exposure could occur if radioactive materials are released into the environment as the result of an accident, an event in nature, or an act of terrorism. Such a release could expose people and contaminate their surroundings and personal property (CDC, 2014f).


Radiation exposure occurs when all or part of the body absorbs penetrating ionizing radiation from an external radiation source. Exposure from an external source stops when a person leaves the area of the source, the source is shielded completely, or the process causing exposure ceases. During exposure, the body may absorb radiation, or it may pass completely through the body. This is similar to what happens during an ordinary chest x-ray. An individual who has been exposed in this way is not radioactive and can be treated like any other patient (ORISE, 2015; CDC, 2014f; REMM, 2016).

Radiation exposure also occurs after internal contamination, ie, when a radioactive material is ingested, inhaled, or absorbed into the bloodstream. This kind of exposure stops only if the radionuclide is eliminated from the body, with or without treatment (REMM, 2016).

An individual exposed only to an external source of radiation, is NOT radioactive or contaminated and may be approached without risk, just as is the case following a chest x-ray or CT scan (REMM, 2016).

Radiation from external exposure alone is either absorbed without the body becoming radioactive, or it can pass through the body completely. Therefore, if a person is scanned with a radiation survey monitor after external exposure alone, the device will not register radiation above the background level (REMM, 2016).

Contamination: External or Internal

Contamination results when a radioisotope (as gas, liquid, or solid) is released into the environment and then ingested, inhaled, or deposited on the body surface. External contamination results when radioactive material is deposited on skin, hair, eyes, or other external structures, much like mud or dust. External contamination stops when the material is removed by shedding contaminated clothes and/or completely washing off the contamination (REMM, 2016a).

Internal contamination results when radioactive material is taken into the body via inhalation or ingestion or open wounds. Internal deposition of radioisotopes in organs results in local exposure at that location. Internal contamination continues until the radioactive material decays, is flushed from the body by natural processes, or is removed by medical countermeasures (REMM, 2016a).


After inhalation, ingestion, or wound contamination, small radioisotope particles may be transported via blood or lymphatics into cells, tissues, and organs. Isotopes can be alpha-, beta-, or gamma-emitting. Radioisotopes can be incorporated into one or more organs specific for that isotope, (eg, thyroid, lungs, kidneys, bones/bone marrow, or liver/spleen) resulting in exposure at that site. Medical countermeasures called decorporation agents or other procedures (eg, diuresis) may be needed to remove radioisotopes that have been incorporated into tissues. Toxic effects of radioisotopes may be due to their chemical and/or radiological properties (REMM, 2016b).

Radiation-Induced Illness

Acute Radiation Syndrome (ARS)

Acute radiation syndrome (ARS)—sometimes known as radiation toxicity or radiation sickness—is an acute illness caused by irradiation of the entire body, or most of the body, by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes) (CDC, 2017e). The most probable terrorist events, such as a dirty bomb attack, will likely generate low levels of radiation exposure. If ARS cases are seen, it is likely that casualty numbers will be small (CDC, 2014g).

Basic symptomatic issues of ARS include:

  • Time of exposure, distance from radioactive source, and duration of exposure
  • Patients may present individually if exposed to radioactive sources that are hidden in the community.
  • Symptoms can be immediate or delayed, mild or severe, based on radiation dose.
  • Nausea and vomiting may occur minutes to days after exposure.
  • Early onset of vomiting followed by symptoms of bone marrow suppression, gastrointestinal destruction, and/or cardiovascular/CNS effects are indicative of acute illness.
  • Depending on the stage of illness, a patient may be asymptomatic. (CDC, 2014g)

The required conditions for ARS are:

  • The radiation dose must be large (> 0.7 Gy, or >70 rads).
  • The dose usually must be external (the source of radiation is outside of the patient’s body).
  • The radiation must be penetrating (able to reach the internal organs).
  • The entire body (or a significant portion of it) must have received the dose.
  • The dose must have been delivered in a short time (usually a matter of minutes). (CDC, 2017e)

The three classic ARS syndromes are:

  • Bone marrow syndrome (hematopoietic syndrome)
  • Gastrointestinal syndrome
  • Cardiovascular (CV)/Central Nervous System (CNS) syndrome (CDC, 2017e)

The four stages of ARS are:

  • Prodromal stage (N-V-D stage): Classic symptoms are nausea, vomiting, and anorexia—and possibly diarrhea, depending on dose—which occur from minutes to days following exposure. The symptoms may last episodically from minutes to several days.
  • Latent stage: The patient looks and feels generally healthy, for a few hours to a few weeks.
  • Manifest illness stage: The symptoms depend on the specific syndrome and last from hours to several months.
  • Recovery or death: Most patients who do not recover will die within several months of exposure. The recovery process lasts from several weeks to 2 years (CDC, 2017e).

Cutaneous Radiation Syndrome (CRS)

The concept of cutaneous radiation syndrome (CRS) was introduced in recent years to describe the complex pathological syndrome that results from acute radiation exposure to the skin.

ARS usually will be accompanied by some skin damage. It is also possible to receive a damaging dose to the skin without symptoms of ARS, especially with acute exposures to beta radiation or X-rays. Sometimes this occurs when radioactive materials contaminate a patient’s skin or clothes.

When the basal cell layer of the skin is damaged by radiation, inflammation, erythema, and dry or moist desquamation can occur. Also, hair follicles may be damaged, causing epilation. Within a few hours after irradiation, a transient and inconsistent erythema (associated with itching) can occur. Then, a latent phase may occur and last from a few days up to several weeks, when intense reddening, blistering, and ulceration of the irradiated site are visible.

In most cases, healing occurs by regenerative means; however, very large skin doses can cause permanent hair loss, damaged sebaceous and sweat glands, atrophy, fibrosis, decreased or increased skin pigmentation, and ulceration or necrosis of the exposed tissue (CDC, 2017e).

Protecting Staff and Patients

The CDC has established general guidelines for managing patients and protecting staff in the event of radiation exposure. These guidelines are specifically designed for small-scale incidents not resulting from a large or nuclear device.

Hospitals and other agencies are also expected to have mass casualty strategies in place, and all appropriate staff should be trained in proper procedures and use of equipment. Many resources are available for establishing triage areas and managing mass casualties (OSHA, 2005).

According to the CDC, addressing contamination issues should not delay treatment of life-threatening injuries. It is highly unlikely that the levels of radioactivity associated with a contaminated patient would pose a significant health risk to care providers. In certain rare instances, the presence of imbedded radioactive fragments or large amounts of external contamination may require expedited decontamination, thus it is recommended to include in-house radiation professionals on the response team (CDC, 2014g). The CDC staff protection guidelines include the following.

Establish an ad hoc triage area:

  • Base it on your hospital’s disaster plan and the anticipated number of casualties.
  • Establish a contaminated area and a clean area separated by a buffer zone.
  • Remove your contaminated outer garments when leaving the contaminated area.
  • Have your body surveyed with a radiation meter when exiting a contaminated area. (CDC 2014g)

Use standard precautions to protect staff:

  • Follow standard guidelines for protection from microbiologic contamination.
  • Surgical masks should be adequate.
  • N-95 masks, if available, are recommended.
  • Survey hands and clothing at frequent intervals with a radiation meter.
  • Due to fetal sensitivity to radiation, assign pregnant staff to other duties. (CDC, 2014g)

Protective Clothing for Staff

The purpose of protective clothing is to keep bare skin and personal clothing free of external contamination. Paper coveralls, cloth coveralls, and surgical garb are all appropriate protective clothing. Because most people are not used to working in extra layers of clothing they should be monitored for heat stress. “Standard issue particulate protective masks (respirators) afford excellent protection from inhalation and ingestion of most radioactive material” (ORISE, 2017).


PPE in Radiation Emergencies

  • In a radiation emergency, the choice of appropriate personal protective equipment (PPE) depends on
    • Response role and specific tasks
    • Risk of contamination
  • PPE can protect against
    • External contamination
    • Internal contamination via inhalation, ingestion, absorption through open wounds
    • Other physical hazards (e.g., debris, fire/heat, or chemicals)
  • PPE cannot protect against exposure from high energy, highly penetrating forms of ionizing radiation associated with most radiation emergencies.
    • Lead aprons worn in diagnostic radiology do not provide sufficient shielding against these kinds of radiation.
  • PPE should include a personal radiation dosimeter whenever there is concern about exposure to penetrating ionizing radiation.
    • Direct-reading personal radiation dosimeters may be used to monitor radiation dose and can help workers stay within recommended Dose Limits for Emergency Workers.
    • Direct-reading dosimeters should be worn so that a worker can easily see the read-out and/or hear warning alarms.
  • Recommended respiratory PPE includes a full-face piece air purifying respirator with a P-100 or High Efficiency Particulate Air (HEPA) filter.
    • Other respiratory protective equipment (e.g., a simple surgical facemask, N-95 respirators), non-fit tested respirators, or ad hoc respiratory protection do not deliver appropriate or sufficient respiratory protection.
    • Environmental testing and hazard assessment by a safety professional can help identify hazards and risk levels and direct choices


More detailed information about forms of PPE and their efficacy is available from the Radiation Emergency Medical Management website:

Decontamination Guidelines for Patients

The CDC offers the following guidelines for managing patients who are believed to have been contaminated either externally or internally with radiation. Before beginning treatment, staff should be sure to take care in following their agency’s guidelines for donning protective clothing or equipment.

Survey the patient with a radiation meter:

  • Perform surveys using consistent technique and trained personnel.
  • Note exceptionally large amounts of surface or embedded radioactive material.
  • Handle radioactive objects with forceps and store in lead containers.
  • Record location and level of any contamination found. (CDC, n.d.)

Remove patient clothing:

  • Carefully cut clothing and roll it away from the face to contain the contamination.
  • Double-bag clothing using radioactive hazardous waste guidelines, label, and save as evidence.
  • Repeat patient survey and record level. (CDC, n.d.)

Cleanse contaminated areas:

  • Wash wounds first with saline or water.
  • If facial contamination is present, flush eyes, nose, and ears, and rinse mouth.
  • Gently cleanse intact skin with soap and water, starting outside the contaminated area and washing inward.
  • Do not irritate or abrade the skin.
  • Resurvey and note levels.
  • Repeat washing until survey indicates radiation level is no more than twice background or the level remains unchanged.
  • Cover wounds with waterproof dressing.
  • Dispose of wastewater through normal channels.
  • For mass casualties, consider establishing separate shower areas for ambulatory and nonambulatory patients. (CDC, n.d.)

Management of deceased:

  • If exposed to a lethal dose of radiation without contamination, a patient is not radioactive and no special precautions are needed.
  • Special precautions may be necessary for contaminated deceased (CDC, n.d.). (CDC and REMM provide detailed guidelines for this situation.)

Initial Evaluation and Treatment

Treat vomiting, and repeat CBC analysis, with special attention to the lymphocyte count, every 2 to 3 hours for the first 8 to 12 hours after exposure (and every 4 to 6 hours for the following 2 to 3 days). Precisely record all clinical symptoms, particularly nausea, vomiting, diarrhea, and itching, reddening, or blistering of the skin. Be sure to include time of onset.

Note and record areas of erythema. If possible, take color photographs of suspected radiation skin damage. Consider tissue and blood typing as well as initiation of viral prophylaxis. Promptly consult with radiation, hematology, and radiotherapy experts about dosimetry, prognosis, and treatment options. Call the Radiation Emergency Assistance Center to record the incident in the Radiation Accident Registry System (see numbers under Resources at the end of this course).

After consultation, begin the following treatment (as indicated):

  • Supportive care in a clean environment (eg, burn unit)
  • Prevention and treatment of infections
  • Stimulation of hematopoiesis by use of growth factors
  • Stem cell transfusions or platelet transfusions (if platelet count too low)
  • Psychological support
  • Careful observation for erythema (document locations), hair loss, skin injury, mucositis, parotitis, weight loss, or fever
  • Confirmation of initial dose estimate, using chromosome aberration cytogenetic bioassay when possible (Although resource-intensive, this is the best method of dose assessment following acute exposures.)
  • Consultation with experts in radiation accident management. (CDC, 2017e)

Internal Contamination

Consider internal contamination if high survey readings persist following decontamination. Internal contamination generally does not cause early symptoms. Nose or mouth contamination may indicate inhalation or ingestion.

To check for internal contamination:

  • Assessment may include analysis of urine, blood, and fecal samples or whole-body counts. Consult with radiation experts.
  • Radiation experts may recommend early administration of radionuclide-specific decorporation agents such as Prussian blue, DTPA, or bicarbonate.
  • Gastric lavage, antacids, and cathartics assist in clearing ingested contaminants. (CDC, n.d.)

Medical Management: Countermeasures

Treating internal contamination:

  • During a radiological or nuclear emergency, radioactive materials may be released into the air and then breathed into the lungs, or may get into the body through open wounds. Radioactive materials can also contaminate the local food supply and get into the body through eating or drinking. This is called internal contamination.
  • The sooner internal contamination is removed from the body, the fewer and less severe the health effects will be. Small amounts of internal contamination may not need treatment.

Some medical treatments are available for limiting or removing internal contamination depending on the type of radioactive material involved. Medical professionals will determine if any of the following treatments are needed:

  • Potassium Iodide (KI)
  • Prussian Blue
  • DTPA (Diethylenetriamine pentaacetate)
  • Neupogen (CDC, 2016d)

Psychosocial Issues

In urban areas, hundreds to thousands may seek care. Most will self-refer to the nearest hospital. While many may need decontamination, others may seek radiologic screening even though not contaminated. Many simply seek reassurance. Mental health professionals should always be members of the response team and available in any first-receiver facility to provide such support.

When evaluating patients, healthcare workers need to understand that psychogenic symptoms, such as nausea or vomiting, may manifest. Keep in mind that vomiting due to radiation exposure is usually recurrent rather than episodic.

Have radiation exposure fact sheets available for patients and families and remember that pregnant patients require special counseling. It is likely that separate areas for radiation screening and counseling will be needed for patients with minimal risk of exposure or injury (CDC, n.d.).

Health Alert Network (HAN)

The Health Alert Network (HAN) is a nationwide communications system established by the CDC and implemented by each state. The Nevada HAN provides a 24/7 means of two-way communication for all critical health information among the Nevada Division of Public and Behavioral Health and local and rural healthcare professionals. These professionals include physicians, nurses, hospitals, laboratories, clinicians, public health workers, emergency management, and others (SNHD, 2017).

The Nevada Health Alert Network (NVHAN) is administered by the Division of Public and Behavioral Health (DPBH), Public Health Preparedness Program (PHP). NVHAN is a statewide, bed tracking, availability and alerting system in place throughout the state.

Its digital, high-speed notification system is used to rapidly contact hospitals and healthcare facilities; or thousands of staff with extreme speed and accuracy.

NVHAN is composed of three systems:

  • HAvBED (Hospital Available Beds for Emergencies and Disasters);
  • NXT Communicator (allows rapid contact of large groups of key individuals); and the
  • Wireless Priority Service (WPS) and Government Emergency Telecommunications Service (GETS) (provide additional communication capabilities in an emergency when wireless or public systems are congested).

Healthcare professionals interested in signing up for NVHAN should visit the Nevada Health Alert Network (NVHAN) website and follow the link to sign up, or for more information contact the administrator at 775 684 3242 (DPBH, 2015).

Healthcare professionals in southern Nevada can also get information from the Southern Nevada Health District HAN Coordinator at 702 759 1299 or sign up at the district’s website (SNHD, 2017).

Alert Message Types

CDC HAN messages range from informational updates of general interest to alerts that require immediate action. Examples of the different types of alerts listed below, as well as archives of past alerts, may be found on the CDC Health Alert Network website.

Health Alert: provides vital, time-sensitive information for a specific incident or situation; warrants immediate action or attention by health officials, laboratorians, clinicians, and members of the public; and conveys the highest level of importance.

Health Advisory: provides important information for a specific incident or situation; contains recommendations or actionable items to be performed by public health officials, laboratorians, and/or clinicians; may not require immediate action.

Health Update: provides updated information regarding an incident or situation; unlikely to require immediate action.

Info Service: provides general public health information; unlikely to require immediate action. (CDC, 2017d)

Resources and References

Nevada Resources

Nevada Department of Health and Human Services

Division of Public and Behavioral Health (DPBH)

4150 Technology Way

Carson City, NV 89706

775 684 4200

Public Health Preparedness (PHP): 775 684 5948

Public health emergency reporting: 775 684 5920

Southern Nevada Health District Main Facility

280 S. Decatur Blvd.

Las Vegas, NV 89107

702 759 1000

702 759 1671 (Emergency Preparedness Office)

Nevada Department of Business and Industry

Division of Industrial Relations

Occupational Safety and Health Administration (OSHA)

Nevada Department of Public Safety

Division of Emergency Management – Homeland Security

2478 Fairview Drive

Carson City, NV 89701

775 687 0300 (non-emergency calls)

775 687 0400 (emergency calls)

Federal Resources

Centers for Disease Control and Prevention (CDC)

1600 Clifton Road

Atlanta, GA 30329

800 232 4636 (800 CDC INFO)

888 232 6348 (TTY)

Emergency Preparedness and Response

Radiation Emergency Assistance Center/Training Site (REAC/TS)

Oak Ridge Institute for Science and Education (ORISE)

PO Box 117, MS-39, Oak Ridge, TN 37831

865 576 3131

865 576 1005 (24-hour emergency # - ask for REAC/TS)

U.S. Department of Health and Human Services (HHS)

Radiation Emergency Medical Management (REMM)

U.S. Department of Homeland Security (DHS)


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