Vaccine Hesitancy Meeting the ChallengePage 6 of 11

Paper 1. The Challenge of Vaccine Hesitancy and Acceptance: An Overview


A doctor talking to a patient about COVID-19 vaccination.


Vaccination is one of the world’s most important medical interventions. Generally safe, effective, and relatively inexpensive, vaccines save about three million lives every year and protect hundreds of millions of people against acute and chronic infections and their consequences (World Health Organization [WHO], 2017). While administering a vaccine is a fairly simple process, the enterprise of vaccination is complex. To invent, test, and produce a vaccine is difficult, and protecting a population of people against infectious diseases requires high levels of organization and participation. 


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