COVID-19 Treatment GuidelinesPage 3 of 15

1. What’s New in the COVID-19 Treatment Guidelines

*This course has been retired. Please click here for new course: COVID NIH Treatment Guidelines.


A doctor explaining what's new in COVID-19 treatment.

U.S. Department of Health and Human Services

This update alert clinicians about the recent rapid increase in certain SARS-CoV-2 Omicron subvariants circulating in the United States. It includes information on the 2021 to 2022 influenza season and recommendations for the upcoming 2022 to 2023 season. It discusses some important limitations of using pulse oximetry to detect hypoxemia. It discusses the management of nonhospitalized patients discharged from the emergency department (ED) and patients discharged after hospitalization. It notes that concerns related to SARS-CoV-2 viral rebound and the recurrence of COVID-19 symptoms should not be a reason to avoid the use of ritonavir-boosted nirmatrelvir. There are minor updates to the following Guidelines sections:

  • Remdesivir
  • Interleukin-6 Inhibitors
  • Vitamin C
  • Vitamin D
  • Zinc


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