COVID-19 Treatment GuidelinesPage 11 of 15

9. Immunomodulators

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U.S. Department of Health and Human Services

The hyperactive inflammatory response to SARS-CoV-2 infection plays a central role in the pathogenesis of COVID-19. This section includes information on the use of the following immunomodulators for hospitalized patients, depending on disease severity: corticosteroids: (dexamethasone); Interleukin-6 inhibitors: (tocilizumab or sarilumab); Janus kinase (JAK) inhibitors: baricitinib (or tofacitinib). 

This section includes additional recommendations about other immunomodulators with insufficient information to make a recommendation and guidance about immunomodulators that the Panel recommends against.


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